Background and Unmet Need Legacy and insensitive high explosives (IHEs), such as 2,4-dinitroanisole (DNAN) and 2-methyl-1,3,5-trinitrobenzene (TN)T, are commonly found in soil at Department of Defense (DoD) testing and training ranges. These ranges maintain very high concentrations of DNAN, which poses a substantial safety concern for personnel as DNAN has been found to possess significant […]
Chemicals
Chemical collections and methods for rapid storage, retrieval and assay are vital for new drug discovery. LIMR Chemical Genomics Center’s (LCGC) large chemical collection covers a unique structural space not covered by other pharma or commercial libraries. LCGC has developed a variety of hardware and software solutions to enable efficient, low-cost drug screens directed to […]
Unmet Need Syntheses of phenethylamines in a rapid and efficient manner. Dr. Adejare’s demonstrated technology can save time, reagents, and number of steps in syntheses of arylalkylamines. The pharmaceutically relevant chemical classes include: phenylethylamines, alpha-alkylphenylethylamines, tryptamines, and arylcyclohexylamines. Opportunity Many fine chemicals, pharmaceutical products, and / or their intermediates can be synthesized using this technology. […]
This invention can be a useful synthetic tool for any company / laboratory that is pursuing the synthesis of benzoxaborole-containing targets. Reagents can be commercialized through a chemical supply company making them available for purchase by academic labs and / or companies. This invention currently is in laboratory use. Opportunity The Tomsho Lab has synthesized […]
A cell-based method to determine surface heterogeneity on polystyrene used in tissue culture flasks and dishes; increasing reliability of outcome of cell assays and reducing necessity to repeat cell-based tests.