Diabetes Mellitus is increasing at an unprecedented pace; more than half a billion people are living with diabetes worldwide. The disease affects men, women, and children of all ages in every country, and that number is projected to more than double to 1.3 billion people in the next 30 years, with every country seeing an […]
Autoimmune & Metabolic Disorders
Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs when the body’s immune system attacks joints, creating debilitating inflammation and pain. Left unchecked this inflammatory condition can permanently damage joint structures, and in some cases, damage the cardiovascular and respiratory systems. This systemic disease affects more than 1.5 million Americans and about 1% of […]
The Glucagon-Like Peptide 1 Receptor (GLP-1R), a member of Class B family of G-protein coupled receptors (GPCRs), is an effective target for the treatment of type-2 diabetes, and its incretin peptide and varied peptide mimetics are adopted drugs. Despite remarkable anti-diabetic effects, GLP-1R peptide-based agonists are limited by several disadvantages. Although considerable progress has been […]