Background and Unmet Need Quaternary ammonium compounds (QACs) are a staple disinfectant in household, agricultural, industrial, and clinical settings. Their popularity has continued to persist due to their broad-spectrum activity against various micro-organisms. While the non-specific mechanism of QACs suggested that these compounds would evade resistance development, unfortunately, tolerance of QACs was eventually observed. Furthermore, […]
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Fortune Business Insights reports that the global fungicide market size was valued at $17.1 billion in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 4.93% to $25.81 billion by 2028. With the expansion of the global fungicide market, which includes manufacturing benzoxaboroles in large quantities, Dr. Tomsho’s protecting group […]
Dr. Sylvie Lorente, Associate Dean for Research and Innovation, College of Engineering; Chair and Professor in Mechanical Engineering at Villanova University, has invented a novel hybrid cooling system that utilizes modular ceramic insert architecture for stationary battery storage systems. The invention ensures batteries are separate from the coolant, while keeping the battery cells within the desired and […]
Targeted and long-lasting formulations of chemotherapeutics with low doses and few side effects. Simple formulations to delivery two or more therapeutics to cancers with similar pharmacokinetic profiles. Easier to manufacture than nano / micro particles. Good to use in combination with immune checkpoint inhibitors. Clinical Applications To sensitize the responses of cancers to chemotherapeutics. rHSA-p53 […]
Chemical collections and methods for rapid storage, retrieval and assay are vital for new drug discovery. LIMR Chemical Genomics Center’s (LCGC) large chemical collection covers a unique structural space not covered by other pharma or commercial libraries. LCGC has developed a variety of hardware and software solutions to enable efficient, low-cost drug screens directed to […]