Diagnostic Tool for Analyzing Results of Flow-Mediated Dilation

Villanova University scientist, Qianhong Wu has developed a novel method to assess the results of a BAFMD test, including a system and device that evaluate the output and results of an FMD process. It produces a diagnostic tool that overcomes the previous issues of interpreting an FMD test.

There is significant potential for the tool to be integrated into an ultrasound system and enable new diagnostic methods. Ultrasound already is used widely in cardiology as an inexpensive, noninvasive diagnostic tool. The global CV ultrasound market was valued at $1.3 billion USD in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 6.7% from 2021 to 2028. The increase in CVD and a rise in preventative screening is expected to be the main stimulant of market growth. This invention could enable a novel diagnostic paradigm for ultrasound manufacturers to differentiate their offerings to cardiologists and other medical practitioners.

In addition to enabling a more nuanced risk assessment of CVDs and other health issues that have already been found to correlate with abnormal FMD, another avenue where this invention could exhibit great potential is monitoring the progress of COVID long haulers. This is borne out by recent evidence that SARS-CoV-2 has been associated with leaky vessels, pointing to a compromised glycocalyx layer, and endothelial function, the evolution of which the model underlying this invention is well-suited to detect.

Finally, there is potential for the invention as a clinical trials support tool. The ability to easily and non-invasively track longitudinal progression of arterial health could be useful for CVD clinical trials. The CVD drug market is expected to reach $63.96B USD by 2026 , however there are concerns about the pipeline of promising candidates. CVD drug trials cost approximately six times that of average trials for other indications , with much of that cost associated with challenges in evidence generation. A new, non-invasive, and inexpensive tool for CVDs could significantly reduce the price of developing new CVD drugs.

Clinical uses:
Diagnostic assessment of cardiovascular diseases.
Diagnostic monitoring of COVID long haulers.

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