Lankenau Institute for Medical Research


Drug Therapy to Rapidly and Safely Correct Cardiac Arrhythmia

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. AF patients exhibit increased risks for heart attacks, heart failure, hospitalization, and death. AF is increasing in prevalence, with up to 15.1M cases estimated annually by 2050 in the USA. This increase is in large part due to aging of the […]

Chemical Genomics Center (LCGC) Pharma Discovery Research Tool

Chemical collections and methods for rapid storage, retrieval and assay are vital for new drug discovery. LIMR Chemical Genomics Center’s (LCGC) large chemical collection covers a unique structural space not covered by other pharma or commercial libraries. LCGC has developed a variety of hardware and software solutions to enable efficient, low-cost drug screens directed to […]

Anti-Bin1 Treatment of Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease, is a debilitating autoimmune condition that is clinically challenging to manage effectively. In the U.S., the CDC estimates that 1.3% of adults (about 3 million) have been diagnosed with IBD. Many IBD patients are diagnosed early in life. As a result of chronic […]

Improved Diagnostic Tools and Structural Vaccines for Lyme Disease

The microbial organism Borrelia burgdorferi causes the common infection termed Lyme disease. This infection is transferred to humans by deer ticks and is common in areas of North America and other countries where large deer populations are found. In the U.S., the CDC has estimated that up to 476,000 cases of Lyme disease were diagnosed […]

Anti-Bin1 Treatment of Alzheimer’s Disease

Human genetics studies have identified Bin1 as second only to ApoE as a risk factor for late-onset Alzheimer’s disease (LOAD). Neurology studies indicate that Bin1 binds and influences the turnover of tau as a likely mechanism in promoting LOAD risk. Lankenau Institute for Medical Research scientists developed a cell-penetrating Bin1 antibody that appears to promote […]